MyPaint is basically a free and relatively more basic alternative to Corel Paint, so as you’d expect, it comes with support for pressure sensitive graphics tablets like the ones from Wacom or Huion. MyPaint supports all the major file formats, has support for layer management, as well as an ‘unlimited canvas’, which means you won’t have to preset the image size before starting off on your painting. It comes with dynamic brush library that simulate pencil, charcoal and ink, but advanced users can also create their own customized brushes to suit their needs. The program focuses more on the painting aspect rather than image manipulation and, comes with a boatload of features that belies its simple user interface.
Unlike Paint.NET, MyPaint is a free and open source (FOSS) alternative to MS Paint that is available on Windows, Mac and Linux.